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CS-W001157 4
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tert-Butyl 3-amino-1H-indazole-1-carboxylate

  • CAS No. 1204298-58-7

  • Cat. No. CS-W007138
  • Purity≥95%
  • MDL No.MFCD12827767

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-amino-1H-indazole-1-carboxylate|CS-W007138

Structure of 1204298-58-7

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General Information

  • CAS No. 1204298-58-7
  • Cat. No. CS-W007138
  • Purity ≥95%
  • MDL No. MFCD12827767
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅N₃O₂
  • Molecular Weight None
  • Synonym(s) 1-Boc-3-aminoindazole
  • SMILES O=C(N1N=C(N)C2=C1C=CC=C2)OC(C)(C)C

Description

tert-Butyl 3-amino-1H-indazole-1-carboxylate features a bench-stable, moisture-tolerant indazole scaffold bearing a strategically positioned amino group. This derivative enables direct incorporation into diverse synthetic routes for bioactive molecules, particularly in kinase inhibitor and pharmaceutical discovery platforms. The tert-butyl ester facilitates convenient deprotection under mild acidic conditions.

Application

tert-Butyl 3-amino-1H-indazole-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to indazole-based scaffolds. The tert-butyl carbamate group provides excellent stability and ease of removal under mild acidic conditions, while the pendant amino group facilitates direct functionalization or coupling reactions. Its compatibility with standard amide coupling, reductive amination, and transition-metal-catalyzed transformations makes it ideal for constructing complex heterocyclic architectures in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.14
  • LogP   2.4017
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   0

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