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CS-W001157 4
Total: USD 88.00

1-(2-Fluoro-6-methoxyphenyl)ethanone

  • CAS No. 120484-50-6

  • Cat. No. CS-W019467
  • Purity≥98%
  • MDL No.MFCD00671762

*For research and further manufacturing use only, not for direct human use.

1-(2-Fluoro-6-methoxyphenyl)ethanone|CS-W019467

Structure of 120484-50-6

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General Information

  • CAS No. 120484-50-6
  • Cat. No. CS-W019467
  • Purity ≥98%
  • MDL No. MFCD00671762
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₂
  • Molecular Weight 168.17
  • Synonym(s) 2'-Fluoro-6'-methoxyacetophenone
  • SMILES CC(C1=C(OC)C=CC=C1F)=O

Description

1-(2-Fluoro-6-methoxyphenyl)ethanone features a fluorinated aromatic ring paired with a methoxy group, delivering enhanced electronic and steric control. This ketone integrates readily into synthetic sequences requiring electron-deficient aryl functionality. The molecule exhibits bench-stable handling characteristics and compatibility with standard reaction conditions in medicinal chemistry and process development workflows.

Application

1-(2-Fluoro-6-methoxyphenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant aryl ketones. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the methoxy group provides a handle for further functionalization. The compound exhibits good bench stability and compatibility with standard coupling reactions, facilitating its use in the synthesis of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
    • 1-(2-Fluoro-6-methoxyphenyl)ethan-1-ol|CS-0378461
      120484-49-3
    • ~72%
    • In-stock
      1-(2-Fluoro-6-methoxyphenyl)ethanone|CS-W019467
      120484-50-6

    References

    • Rhizen Pharmaceuticals SA Patent: US2012/289496 A1, 2012 ; Location in patent: Page/Page column 100 ;
  • Route2

    References

    • Akzo Nobel Patent: US6645973 B1, 2003 ;
  • Route3
    • null|null
      75-16-1
    • In-stock
      2-Fluoro-6-methoxybenzonitrile|CS-0009963
      94088-46-7
    • ~%
    • In-stock
      1-(2-Fluoro-6-methoxyphenyl)ethanone|CS-W019467
      120484-50-6

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 619 - 622

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.0369
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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