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CS-W001157 4
Total: USD 88.00

2-Chloro-5-(trifluoromethoxy)pyridine

  • CAS No. 1206972-45-3

  • Cat. No. CS-D0406
  • Purity≥95%
  • MDL No.MFCD18257007

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-(trifluoromethoxy)pyridine|CS-D0406

Structure of 1206972-45-3

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General Information

  • CAS No. 1206972-45-3
  • Cat. No. CS-D0406
  • Purity ≥95%
  • MDL No. MFCD18257007
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClF₃NO
  • Molecular Weight 197.54
  • Synonym(s) 2-Chloro-5-(trifluoromethoxy)
  • SMILES FC(F)(F)OC1=CN=C(Cl)C=C1

Description

2-Chloro-5-(trifluoromethoxy)pyridine features a trifluoromethoxy group that imparts enhanced electron-withdrawal and metabolic stability, while the chloro substituent enables direct functionalization in cross-coupling reactions. This combination facilitates efficient access to advanced pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

2-Chloro-5-(trifluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the C2 position. The trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the chlorine substituent offers compatibility with Suzuki, Negishi, and Buchwald–Hartwig coupling protocols. Its bench-stable nature and ease of purification support scalable synthesis of bioactive heterocycles and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.6336
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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