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Structure of 1206972-45-3
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2-Chloro-5-(trifluoromethoxy)pyridine features a trifluoromethoxy group that imparts enhanced electron-withdrawal and metabolic stability, while the chloro substituent enables direct functionalization in cross-coupling reactions. This combination facilitates efficient access to advanced pharmaceutical intermediates and agrochemical scaffolds under standard conditions.
2-Chloro-5-(trifluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the C2 position. The trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the chlorine substituent offers compatibility with Suzuki, Negishi, and Buchwald–Hartwig coupling protocols. Its bench-stable nature and ease of purification support scalable synthesis of bioactive heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: