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CS-W001157 4
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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

  • CAS No. 1207623-97-9

  • Cat. No. CS-0050745
  • Molecule weight260.10
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one|CS-0050745

Structure of 1207623-97-9

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General Information

  • CAS No. 1207623-97-9
  • Cat. No. CS-0050745
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₇BN₂O₃
  • Molecular Weight 260.10
  • Synonym(s) 7-Aza-2-oxindole-5-boronic acid pinacol ester
  • SMILES CC1(C)OB(OC1(C)C)C1=CN=C2NC(=O)CC2=C1

Description

This boronate-functionalized pyrrolopyridone integrates readily into Suzuki-Miyaura coupling reactions under standard conditions. The tetramethylboronate moiety ensures high stability and compatibility with diverse reaction environments, enabling efficient C–C bond formation in synthetic and medicinal chemistry workflows.

Application

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one serves as a versatile boron-containing building block for Suzuki-Miyaura coupling reactions. The pyrrolo[2,3-b]pyridin-2-one core provides a rigid, nitrogen-rich scaffold relevant to bioactive molecule synthesis. Its stability under ambient conditions and compatibility with diverse functional groups enable efficient late-stage diversification in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • KUDOS PHARMACEUTICALS LIMITED Patent: WO2008/23161 A1, 2008 ; Location in patent: Page/Page column 111 ; WO 2008/023161 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   60.45
  • LogP   0.8754
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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