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CS-W001157 4
Total: USD 88.00

2-chloro-4-iodopyridin-3-ol

  • CAS No. 1207973-15-6

  • Cat. No. CS-W000740
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-chloro-4-iodopyridin-3-ol|CS-W000740

Structure of 1207973-15-6

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General Information

  • CAS No. 1207973-15-6
  • Cat. No. CS-W000740
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClINO
  • Molecular Weight 255.44
  • Synonym(s) 2-Chloro-4-iodo-3-pyridinol
  • SMILES Oc1c(I)ccnc1Cl

Description

2-Chloro-4-iodopyridin-3-ol features a pyridin-3-ol core functionalized with chlorine at the 2-position and iodine at the 4-position, enabling direct coupling in cross-coupling reactions. The phenolic hydroxyl group offers a handle for derivatization, while the halogenated sites provide orthogonal reactivity. This compound exhibits bench-stable handling characteristics and compatibility with palladium-catalyzed transformations.

Application

2-Chloro-4-iodopyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The chloro group facilitates nucleophilic substitution or transition-metal-catalyzed coupling, while the iodo substituent offers high reactivity in Suzuki, Stille, and Negishi couplings. Its phenolic hydroxyl group provides a handle for derivatization and enhances solubility, contributing to favorable handling and purification characteristics in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.0452
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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