2-Chloro-3-pyridinol

Name: 2-Chloro-3-pyridinol
Brand: ChemScene
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CAS No. 6636-78-8
Cat. No. CS-D0978
Purity≥98%
MDL No.MFCD00006235

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Description

2-Chloro-3-hydroxypyridine has been used in the preparation of 3-hydroxypyridine-2( 1 H)-selone. It has also been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles: benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine. the synthesis involves and -activation of chloropyridines, as well as palladium-mediated reactions.

Application

2-Chloro-3-pyridinol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C3 position of the pyridine ring. Its chloride moiety facilitates nucleophilic substitution reactions, while the phenolic hydroxyl group provides a handle for derivatization or metal-catalyzed coupling processes. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.

General Information

CAS No. 6636-78-8
Cat. No. CS-D0978
Purity ≥98%
MDL No. MFCD00006235
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClNO
Molecular Weight 129.55
Synonym(s) None
SMILES OC1=CC=CN=C1Cl

Computational Chemistry Data

TPSA 33.12
LogP 1.4406
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2-Chloro-3-pyridinol

CAS No. 6636-78-8

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