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Structure of 1207973-15-6
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2-Chloro-4-iodopyridin-3-ol features a pyridin-3-ol core functionalized with chlorine at the 2-position and iodine at the 4-position, enabling direct coupling in cross-coupling reactions. The phenolic hydroxyl group offers a handle for derivatization, while the halogenated sites provide orthogonal reactivity. This compound exhibits bench-stable handling characteristics and compatibility with palladium-catalyzed transformations.
2-Chloro-4-iodopyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The chloro group facilitates nucleophilic substitution or transition-metal-catalyzed coupling, while the iodo substituent offers high reactivity in Suzuki, Stille, and Negishi couplings. Its phenolic hydroxyl group provides a handle for derivatization and enhances solubility, contributing to favorable handling and purification characteristics in synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319
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Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: