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6-Chloroimidazo[1,2-b]pyridazine-3-carboxylic acid

  • CAS No. 1208084-53-0

  • Cat. No. CS-0037265
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloroimidazo[1,2-b]pyridazine-3-carboxylic acid|CS-0037265

Structure of 1208084-53-0

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General Information

  • CAS No. 1208084-53-0
  • Cat. No. CS-0037265
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClN₃O₂
  • Molecular Weight 197.58
  • Synonym(s) None
  • SMILES C1=CC2=NC=C(C(=O)O)N2N=C1Cl

Description

6-Chloroimidazo[1,2-b]pyridazine-3-carboxylic acid is a heterocyclic building block featuring a chlorine substituent at the 6-position and a carboxylic acid group at the 3-position. This combination imparts enhanced reactivity in coupling reactions and improves solubility in polar solvents. The molecule integrates readily into medicinal chemistry scaffolds, particularly for kinase inhibitors and targeted therapeutics. Bench-stable under standard conditions, it supports efficient derivatization workflows.

Application

6-Chloroimidazo[1,2-b]pyridazine-3-carboxylic acid serves as a versatile building block for heterocyclic scaffolds in medicinal chemistry. Its chloro and carboxylic acid functionalities enable direct derivatization via nucleophilic substitution and amide coupling, respectively. The molecule exhibits bench stability and compatibility with standard reaction conditions, facilitating efficient synthesis of imidazopyridazine-based API candidates and functionalized intermediates in drug discovery workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.49
  • LogP   1.0809
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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