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CS-W001157 4
Total: USD 88.00

2-Bromopyrimidine-4-carbonitrile

  • CAS No. 1209459-16-4

  • Cat. No. CS-W021628
  • Purity≥98%
  • MDL No.MFCD13193321
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Bromopyrimidine-4-carbonitrile|CS-W021628

Structure of 1209459-16-4

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Description

2-Bromopyrimidine-4-carbonitrile features a bromine atom at the 2-position and a nitrile group at the 4-position on a pyrimidine scaffold, delivering a potent electrophilic handle for nucleophilic substitution. This dual functionality enables efficient coupling in cross-coupling reactions and facilitates the synthesis of complex heterocyclic architectures. The molecule exhibits enhanced reactivity due to the electron-withdrawing nature of both substituents, allowing for selective functionalization under mild conditions. Its bench-stable form simplifies handling in synthetic workflows.

Application

2-Bromopyrimidine-4-carbonitrile serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine and electron-deficient pyrimidine core. The nitrile group provides additional handle for functionalization, while the molecule exhibits bench stability and compatibility with standard purification methods. It functions effectively in the construction of bioactive scaffolds and pharmaceutical intermediates.

General Information

  • CAS No. 1209459-16-4
  • Cat. No. CS-W021628
  • Purity ≥98%
  • MDL No. MFCD13193321
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrN₃
  • Molecular Weight 183.99
  • Synonym(s) 2-Bromo-4-pyrimidinecarbonitrile
  • SMILES BrC1=NC(=CC=N1)C#N

Computational Chemistry Data

  • TPSA   49.57
  • LogP   1.11078
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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