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CS-W001157 4
Total: USD 88.00

4-Bromo-2-cyclopropoxypyridine

  • CAS No. 1209460-14-9

  • Cat. No. CS-0097668
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-cyclopropoxypyridine|CS-0097668

Structure of 1209460-14-9

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General Information

  • CAS No. 1209460-14-9
  • Cat. No. CS-0097668
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO
  • Molecular Weight 214.06
  • Synonym(s) None
  • SMILES BrC1=CC(OC2CC2)=NC=C1

Description

4-Bromo-2-cyclopropoxypyridine features a cyclopropoxy group at the 2-position and a bromine atom at the 4-position of the pyridine ring, enabling efficient coupling in cross-coupling reactions. The sterically constrained cyclopropyl moiety enhances stability and modulates electronic properties, making this scaffold valuable for medicinal chemistry and materials synthesis under standard conditions.

Application

4-Bromo-2-cyclopropoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to install aryl and heteroaryl extensions. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the cyclopropoxy group offers metabolic stability and favorable lipophilicity. Its bench-stable solid form facilitates handling and purification, making it suitable for iterative synthesis of bioactive heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.3853
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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