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Structure of 886373-28-0
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5-Bromo-3-fluoropicolinonitrile features a trifunctional pyridine core bearing bromo, fluoro, and nitrile groups at strategic positions. This electron-deficient heterocycle enables direct coupling in cross-coupling reactions and serves as a key intermediate in medicinal chemistry for constructing bioactive scaffolds.
5-Bromo-3-fluoropicolinonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 5-position via palladium-catalyzed cross-coupling reactions. The fluorine and nitrile groups provide orthogonal reactivity for downstream modifications, while the bromine facilitates Suzuki, Stille, or Negishi couplings. Its bench-stable crystalline form simplifies handling and purification, making it ideal for constructing complex heterocyclic scaffolds and API intermediates in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H318
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Precautionary Statements : P264-P270-P280-P302+P352-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: