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CS-W001157 4
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2-Bromo-5-(trifluoromethyl)pyridin-3-amine

  • CAS No. 1211515-87-5

  • Cat. No. CS-0041613
  • Molecule weight241.01
  • Purity≥98%
  • MDL No.MFCD14702313

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-(trifluoromethyl)pyridin-3-amine|CS-0041613

Structure of 1211515-87-5

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General Information

  • CAS No. 1211515-87-5
  • Cat. No. CS-0041613
  • Purity ≥98%
  • MDL No. MFCD14702313
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₃N₂
  • Molecular Weight 241.01
  • Synonym(s) 2-Bromo-5-trifluoromethyl-pyridin-3-ylamine
  • SMILES NC1=CC(=CN=C1Br)C(F)(F)F

Description

2-Bromo-5-(trifluoromethyl)pyridin-3-amine features a bromine atom at the 2-position and a trifluoromethyl group at the 5-position on a pyridine ring bearing a primary amine at the 3-position. This electron-deficient heterocycle integrates readily into cross-coupling reactions, enabling efficient access to functionalized pharmaceutical intermediates under standard conditions.

Application

2-Bromo-5-(trifluoromethyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromide and amine functionalities. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridine scaffold provides favorable pharmacokinetic properties. This compound exhibits good bench stability and compatibility with standard coupling protocols, facilitating efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.4451
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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