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CS-W001157 4
Total: USD 88.00

5-Bromo-2-fluoro-4-methoxypyridine

  • CAS No. 1211588-65-6

  • Cat. No. CS-0130955
  • Purity≥97%
  • MDL No.MFCD18255778

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-fluoro-4-methoxypyridine|CS-0130955

Structure of 1211588-65-6

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General Information

  • CAS No. 1211588-65-6
  • Cat. No. CS-0130955
  • Purity ≥97%
  • MDL No. MFCD18255778
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFNO
  • Molecular Weight 206.01
  • Synonym(s) None
  • SMILES COC1=CC(F)=NC=C1Br

Description

5-Bromo-2-fluoro-4-methoxypyridine is a fluorinated pyridine derivative featuring complementary halogen handles for cross-coupling reactions. The electron-deficient ring facilitates palladium-catalyzed transformations, while the methoxy group enhances solubility and modulates reactivity. This bench-stable compound serves as a key building block in medicinal chemistry and agrochemical synthesis.

Application

5-Bromo-2-fluoro-4-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, or Negishi coupling, while the fluorine supports directed metalation and electrophilic substitution. Its methoxy substituent enhances solubility and modulates electronic properties, offering favorable handling and purification characteristics for scalable synthesis of heterocyclic APIs and agrochemical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.9918
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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