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cis-Methyl 3-aminocyclobutanecarboxylate hydrochloride

  • CAS No. 1212304-86-3

  • Cat. No. CS-W022617
  • Molecule weight165.62
  • Purity≥97%
  • MDL No.MFCD11099895

*For research and further manufacturing use only, not for direct human use.

cis-Methyl 3-aminocyclobutanecarboxylate hydrochloride|CS-W022617

Structure of 1212304-86-3

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General Information

  • CAS No. 1212304-86-3
  • Cat. No. CS-W022617
  • Purity ≥97%
  • MDL No. MFCD11099895
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO₂
  • Molecular Weight 165.62
  • Synonym(s) None
  • SMILES C(OC)(=O)[C@@H]1C[C@H](N)C1.Cl

Description

cis-Methyl 3-aminocyclobutanecarboxylate hydrochloride features a rigid, stereochemically defined cyclobutane core with a pendant amine and ester functional group. This bench-stable derivative enables direct incorporation into peptide-like scaffolds, offering enhanced conformational control in medicinal chemistry applications.

Application

cis-Methyl 3-aminocyclobutanecarboxylate hydrochloride serves as a valuable chiral building block in medicinal chemistry, enabling the construction of cyclobutane-containing scaffolds prevalent in bioactive molecules. The constrained cyclobutane ring imparts rigidity to peptide mimetics and small-molecule drug candidates, while the amine and ester functionalities offer orthogonal handles for further functionalization. Its crystalline hydrochloride salt form ensures excellent bench stability, ease of handling, and straightforward purification—ideal for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.3185
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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