4-Bromo-8-chloroisoquinoline

Name: 4-Bromo-8-chloroisoquinoline
Brand: ChemScene
Availability: InStock
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CAS No. 1215767-86-4
Cat. No. CS-0455290
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

4-Bromo-8-chloroisoquinoline is a halogenated isoquinoline derivative featuring complementary reactive sites at the 4- and 8-positions. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions, serving as a key building block for pharmaceutical intermediates and advanced materials. The molecule exhibits enhanced stability under standard conditions and integrates readily into complex heterocyclic architectures.

Application

4-Bromo-8-chloroisoquinoline serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of complex isoquinoline-based scaffolds. Its complementary halogenation pattern supports sequential functionalization via Pd- or Ni-catalyzed coupling, with excellent bench stability and straightforward purification. Functions effectively in the synthesis of pharmaceutical intermediates and bioactive heterocycles.

General Information

CAS No. 1215767-86-4
Cat. No. CS-0455290
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅BrClN
Molecular Weight 242.50
Synonym(s) 4-bromo-8-chloroisoquinoline4-bromo-8-chloroisoquinoline
SMILES C1=CC2=C(C=NC=C2Br)C(=C1)Cl

Computational Chemistry Data

TPSA 12.89
LogP 3.6507
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Isoquinoline compounds

Key Words

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4-Bromo-8-chloroisoquinoline

CAS No. 1215767-86-4

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