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CS-W001157 4
Total: USD 88.00

1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde

  • CAS No. 1216244-84-6

  • Cat. No. CS-0438088
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde|CS-0438088

Structure of 1216244-84-6

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Description

1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde features a unique difluoromethyl group attached to a pyrazole scaffold, delivering enhanced metabolic stability and altered electronic properties. This electron-deficient aldehyde integrates readily into bioactive molecule synthesis, enabling efficient coupling reactions under mild conditions. The conjugated system supports precise tuning of reactivity in medicinal chemistry applications.

Application

1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde serves as a versatile building block for fluorinated heterocycles, enabling efficient access to bioactive scaffolds via standard condensation and coupling reactions. Its difluoromethyl group enhances metabolic stability and modulates electronic properties, while the aldehyde functionality supports facile derivatization under mild conditions. The compound exhibits excellent bench stability and compatibility with common protecting groups, facilitating its use in medicinal chemistry and process-oriented synthesis workflows.

General Information

  • CAS No. 1216244-84-6
  • Cat. No. CS-0438088
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄F₂N₂O
  • Molecular Weight 146.09
  • Synonym(s) None
  • SMILES O=CC1=CN(C(F)F)N=C1

Computational Chemistry Data

  • TPSA   34.89
  • LogP   1.0907
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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