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Structure of 121629-16-1
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1-(4,4-Difluorocyclohexyl)ethan-1-one features a sterically hindered cyclohexyl core with two fluorine atoms at the geminal 4-position, imparting enhanced metabolic stability and lipophilicity. This difluorinated ketone serves as a key building block in medicinal chemistry for probing bioactive conformational preferences and improving membrane permeability in CNS-targeted compounds.
1-(4,4-Difluorocyclohexyl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling the incorporation of a rigid, lipophilic difluorocyclohexyl moiety into target molecules. The ketone functionality facilitates downstream transformations such as reductive amination, Grignard additions, and nucleophilic conjugate additions. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis campaigns and API scaffold development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: