2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde

Name: 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde
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CAS No. 121660-37-5
Cat. No. CS-0156035
Purity≥97%
MDL No.MFCD09032925

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde|CS-0156035

Structure of 121660-37-5

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Description

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde features a rigid quinoline core functionalized with a cyclopropyl group and a 4-fluorophenyl substituent, enhancing lipophilicity and metabolic stability. The aldehyde handle enables direct coupling in Suzuki-Miyaura and Ullmann reactions, facilitating rapid access to bioactive heterocycles. This scaffold exhibits strong electron-withdrawing character, ideal for conjugated systems in photophysical applications.

Application

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of quinoline-based scaffolds with defined spatial and electronic properties. The aldehyde functionality facilitates key transformations such as reductive amination, Wittig reactions, and nucleophilic additions, while the cyclopropyl and 4-fluorophenyl substituents enhance metabolic stability and modulate lipophilicity. Its bench-stable crystalline form simplifies handling and purification, supporting scalable applications in target-oriented synthesis.

General Information

CAS No. 121660-37-5
Cat. No. CS-0156035
Purity ≥97%
MDL No. MFCD09032925
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₉H₁₄FNO
Molecular Weight 291.32
Synonym(s) 4-(4-FLUOROPHENYL)-2-(CYCLOPROPYL)-3-QUINOLINECARBOXALDEHYDE
SMILES C1=CC=C2C(=C1)C(=C(C=O)C(=N2)C3CC3)C4=CC=C(C=C4)F

Computational Chemistry Data

TPSA 29.96
LogP 4.7308
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde

CAS No. 121660-37-5

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