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CS-W001157 4
Total: USD 88.00

Thalidomide-5-COOH

  • CAS No. 1216805-11-6

  • Cat. No. CS-0204090
  • Purity≥98%
  • MDL No.MFCD32063447

*For research and further manufacturing use only, not for direct human use.

Thalidomide-5-COOH|CS-0204090

Structure of 1216805-11-6

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General Information

  • CAS No. 1216805-11-6
  • Cat. No. CS-0204090
  • Purity ≥98%
  • MDL No. MFCD32063447
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₀N₂O₆
  • Molecular Weight 302.24
  • Synonym(s) None
  • SMILES O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)O

Description

Thalidomide-5-COOH features a carboxylic acid group at the 5-position of the phthalimide core, enhancing solubility and enabling conjugation for targeted delivery. This derivative maintains the pharmacophoric scaffold critical for immunomodulatory activity while offering improved functionalization potential in medicinal chemistry applications.

Application

Thalidomide-5-COOH serves as a key synthetic intermediate for the construction of glutarimide-based scaffolds in medicinal chemistry. Its carboxylic acid functionality enables direct conjugation via amide or ester formation, facilitating targeted derivatization for PROTACs and other protein degraders. The molecule exhibits bench-stable handling and tolerates common reaction conditions, supporting its use in iterative synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   120.85
  • LogP   -0.4055
  • H_Acceptors   8
  • H_Donors   2
  • Rotatable_Bonds   2

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