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Structure of 1216805-11-6
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Thalidomide-5-COOH features a carboxylic acid group at the 5-position of the phthalimide core, enhancing solubility and enabling conjugation for targeted delivery. This derivative maintains the pharmacophoric scaffold critical for immunomodulatory activity while offering improved functionalization potential in medicinal chemistry applications.
Thalidomide-5-COOH serves as a key synthetic intermediate for the construction of glutarimide-based scaffolds in medicinal chemistry. Its carboxylic acid functionality enables direct conjugation via amide or ester formation, facilitating targeted derivatization for PROTACs and other protein degraders. The molecule exhibits bench-stable handling and tolerates common reaction conditions, supporting its use in iterative synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: