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(9H-Fluoren-9-yl)MethOxy]Carbonyl D-2-Carbamoylphe

  • CAS No. 1217759-04-0

  • Cat. No. CS-0179048
  • Molecule weight430.45
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(9H-Fluoren-9-yl)MethOxy]Carbonyl D-2-Carbamoylphe|CS-0179048

Structure of 1217759-04-0

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General Information

  • CAS No. 1217759-04-0
  • Cat. No. CS-0179048
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₂N₂O₅
  • Molecular Weight 430.45
  • Synonym(s) FMOC-D-2-CARBAMOYLPHE
  • SMILES O=C(O)[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)CC4=CC=CC=C4C(N)=O

Description

Fmoc-D-2-carbamoylphenylalanine is a protected D-amino acid derivative designed for solid-phase peptide synthesis. The fluorenylmethoxy carbonyl (Fmoc) group enables orthogonal protection, while the D-configuration imparts conformational stability. This residue integrates efficiently into peptide chains, offering enhanced resistance to proteolytic degradation in bioactive sequences.

Application

(9H-Fluoren-9-yl)methoxycarbonyl D-2-carbamoylphenylalanine serves as a protected amino acid building block for peptide synthesis, enabling orthogonal side-chain protection and efficient coupling under standard conditions. The fluorenylmethoxycarbonyl (Fmoc) group ensures high stability during storage and mild deprotection with piperidine, while the D-2-carbamoylphenylalanine moiety provides a rigid, polar aromatic scaffold suitable for medicinal chemistry applications requiring conformational restraint and enhanced solubility.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   118.72
  • LogP   3.3199
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   7

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