2-(3-Aminopropyl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride

Name: 2-(3-Aminopropyl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 121821-01-0
Cat. No. CS-0075511
Purity≥97%
MDL No.MFCD00035196

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2-(3-Aminopropyl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride|CS-0075511

Structure of 121821-01-0

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General Information

CAS No. 121821-01-0
Cat. No. CS-0075511
Purity ≥97%
MDL No. MFCD00035196
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₃ClN₂O₂
Molecular Weight 240.69
Synonym(s) 2-(3-AMINOPROPYL)-1H-ISOINDOLE-1,3(2H)-DIONE, HCL SALT
SMILES O=C(C1=C2C=CC=C1)N(C2=O)CCCN.Cl

Description

This hydrochloride salt features a functionalized isoindole core with a primary amine at the 3-position, enabling straightforward conjugation in bioconjugation workflows. The dihydroisoindole scaffold offers enhanced solubility and stability under standard conditions, while the protonated amine ensures efficient handling in aqueous systems.

Application

2-(3-Aminopropyl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The pendant amine enables facile derivatization via alkylation, acylation, or reductive amination, while the isoindole-1,3-dione core offers robust stability and compatibility with diverse reaction conditions. Its crystalline solid form facilitates handling and purification, making it suitable for scalable synthetic workflows in medicinal chemistry and process development.

Synthesis

Route1
- 22641-00-5
- ~97%
- In-stock
  
  121821-01-0
References
- Iwata, Masaaki; Kuzuhara, Hiroyoshi Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 198 - 210
Route2
- 10513-96-9
- ~%
- In-stock
  
  121821-01-0
References
- Iwata, Masaaki; Kuzuhara, Hiroyoshi Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 198 - 210

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P264-P280-P305+P351+P338-P337+P313

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Computational Chemistry Data

TPSA 63.4
LogP 1.0532
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Key Words

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2-(3-Aminopropyl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride

CAS No. 121821-01-0

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