3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine

Name: 3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine
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CAS No. 1225-64-5
Cat. No. CS-0571112
Purity≥98%
MDL No.MFCD22666252

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3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine|CS-0571112

Structure of 1225-64-5

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Description

A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks; IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). It shows no significant effect (IC50 >10 M) on the activities of PKC, p38, PDGFR, or EGFR. Inhibits the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.

General Information

CAS No. 1225-64-5
Cat. No. CS-0571112
Purity ≥98%
MDL No. MFCD22666252
Storage Sealed in dry,2-8℃
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₁₇ClN₂S
Molecular Weight 304.84
Synonym(s) Norchlorpromazine
SMILES CNCCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl

Computational Chemistry Data

TPSA 15.27
LogP 4.5522
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 4

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Key Words

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3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine

CAS No. 1225-64-5

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