2-Chloro-3-methoxypyridin-4-amine

Name: 2-Chloro-3-methoxypyridin-4-amine
Brand: ChemScene
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CAS No. 1227600-23-8
Cat. No. CS-0148313
Purity≥96%
MDL No.MFCD11553128

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-3-methoxypyridin-4-amine|CS-0148313

Structure of 1227600-23-8

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Description

2-Chloro-3-methoxypyridin-4-amine features a pyridine core bearing chlorine and methoxy substituents at adjacent positions, enabling selective coupling reactions. The amine functionality provides a reactive handle for diversification in medicinal chemistry applications. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and agrochemicals.

Application

2-Chloro-3-methoxypyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridine moiety. The methoxy and amino groups provide orthogonal functional handles for sequential derivatization, while the compound exhibits excellent bench stability and compatibility with standard purification methods.

General Information

CAS No. 1227600-23-8
Cat. No. CS-0148313
Purity ≥96%
MDL No. MFCD11553128
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) 4-Pyridinamine, 2-chloro-3-methoxy-
SMILES ClC1=NC=CC(N)=C1OC

Computational Chemistry Data

TPSA 48.14
LogP 1.3258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-3-methoxypyridin-4-amine

CAS No. 1227600-23-8

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