6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-cyclopropyl-4-fluoro-2-methyl-1H-benzo[d]imidazole

Name: 6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-cyclopropyl-4-fluoro-2-methyl-1H-benzo[d]imidazole
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1231930-43-0
Cat. No. CS-0435587
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-cyclopropyl-4-fluoro-2-methyl-1H-benzo[d]imidazole|CS-0435587

Structure of 1231930-43-0

Size

Price

Quantity

* Please select Quantity before adding items.

Description

This fluorinated benzoimidazole integrates a cyclopropyl group and a chloro-fluoropyrimidine moiety, delivering enhanced metabolic stability and target affinity. Designed for precision in medicinal chemistry, it serves as a key scaffold in kinase inhibitor development, offering improved solubility and robust performance under standard reaction conditions.

Application

6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-cyclopropyl-4-fluoro-2-methyl-1H-benzo[d]imidazole serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase-inhibitor scaffolds. Its pyrimidine core facilitates palladium-catalyzed cross-coupling reactions, while the benzoimidazole framework offers robust stability and favorable pharmacophore properties. The molecule exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis campaigns in drug discovery.

General Information

CAS No. 1231930-43-0
Cat. No. CS-0435587
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₁₁ClF₂N₄
Molecular Weight 320.72
Synonym(s) None
SMILES CC1=NC2=C(F)C=C(C3=NC(Cl)=NC=C3F)C=C2N1C4CC4

Computational Chemistry Data

TPSA 43.6
LogP 4.06822
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Benzimidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

1231930-43-0 sigma1231930-43-0 manufacturer1231930-43-0 price1231930-43-0 structure1231930-43-0 SDSbuy 1231930-43-01231930-43-0 supplier1231930-43-0 uses1231930-43-0 molecular weightprice of 1231930-43-01231930-43-0 chemical name formula of 1231930-43-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-cyclopropyl-4-fluoro-2-methyl-1H-benzo[d]imidazole

CAS No. 1231930-43-0

Recommended Products