Fmoc-β-D-HoTyr(tBu)-OH

Name: Fmoc-β-D-HoTyr(tBu)-OH
Brand: ChemScene
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CAS No. 1233495-02-7
Cat. No. CS-0187432
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-β-D-HoTyr(tBu)-OH is a stereochemically defined amino acid derivative featuring a β-hydroxytyrosine scaffold with a tert-butyl protected phenolic hydroxyl. This bench-stable building block integrates readily into peptide chains, enabling the introduction of a polar, hydrogen-bonding moiety at defined positions within synthetic sequences.

Application

Fmoc-β-D-HoTyr(tBu)-OH serves as a valuable building block for the synthesis of peptide conjugates and peptidomimetics, enabling site-specific incorporation of β-hydroxytyrosine derivatives. The Fmoc group provides orthogonal protection for amine functionality, while the tert-butyl ether ensures stability during standard solid-phase peptide synthesis. Its D-stereoisomer configuration offers enhanced metabolic resistance, and the β-hydroxyl group facilitates downstream functionalization or hydrogen bonding in bioactive scaffolds.

General Information

CAS No. 1233495-02-7
Cat. No. CS-0187432
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₉H₃₁NO₅
Molecular Weight 473.56
Synonym(s) FMoc-D-β-Hotyr(OtBu)-OH
SMILES CC(C)(OC1=CC=C(C[C@@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)CC(O)=O)C=C1)C

Computational Chemistry Data

TPSA 84.86
LogP 5.7884
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 8

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Ether

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Tyrosine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-β-D-HoTyr(tBu)-OH

CAS No. 1233495-02-7

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