4-Chloro-8-fluoroquinazoline

Name: 4-Chloro-8-fluoroquinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 124429-27-2
Cat. No. CS-0018877
Purity≥95%
MDL No.MFCD09837193

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 124429-27-2

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Description

4-Chloro-8-fluoroquinazoline features a fused bicyclic core with strategically positioned halogen substituents, enabling direct functionalization in late-stage synthesis. The electron-deficient quinazoline scaffold facilitates efficient coupling reactions, while the ortho-halogen arrangement enhances regioselectivity in cross-coupling transformations under standard conditions. This compound serves as a key building block for bioactive heterocycles.

Application

4-Chloro-8-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at C4 and C8 positions via palladium-catalyzed cross-coupling reactions. Its dual halogenation pattern supports sequential derivatization, while the electron-deficient quinazoline core enhances reactivity in nucleophilic substitution and transition-metal-catalyzed transformations. Bench-stable and compatible with standard purification methods, it facilitates efficient access to diverse heterocyclic scaffolds relevant to kinase inhibitor development.

General Information

CAS No. 124429-27-2
Cat. No. CS-0018877
Purity ≥95%
MDL No. MFCD09837193
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄ClFN₂
Molecular Weight 182.58
Synonym(s) None
SMILES FC1=CC=CC2=C(Cl)N=CN=C12

Computational Chemistry Data

TPSA 25.78
LogP 2.4223
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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4-Chloro-8-fluoroquinazoline

CAS No. 124429-27-2

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