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Structure of 1246372-66-6
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This boronate-functionalized nicotinonitrile integrates readily into Suzuki-Miyaura coupling reactions under standard conditions. The tetramethyl-dioxaborolane moiety provides exceptional stability and moisture tolerance, enabling efficient cross-coupling with aryl halides. The para-nitrogen functionality enhances electronic modulation in complex heterocyclic systems, offering a reliable handle for constructing bioactive scaffolds.
2-Amino-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-nicotinonitrile serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate moiety enables stable, room-temperature handling and broad functional group tolerance. It facilitates efficient C–C bond formation with aryl and heteroaryl halides, making it ideal for constructing substituted nicotinonitrile scaffolds commonly found in medicinal chemistry and agrochemical research.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: