(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid

Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid
Brand: ChemScene
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CAS No. 1247791-23-6
Cat. No. CS-0375938
Purity≥98%
MDL No.MFCD06796896

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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid|CS-0375938

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Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid features a bench-stable fluorenylmethoxycarbonyl (Fmoc) protecting group and a sulfonated aliphatic side chain. This combination enables efficient incorporation into peptide synthesis workflows, offering enhanced solubility and stability during automated and manual coupling procedures.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid serves as a versatile chiral building block for peptide synthesis and medicinal chemistry applications. The fluorenylmethoxycarbonyl (Fmoc) group enables orthogonal protection of primary amines, while the methylsulfonyl moiety provides enhanced solubility and metabolic stability. This compound exhibits excellent bench stability, facilitates straightforward purification, and participates reliably in standard coupling reactions, making it well-suited for solid-phase and solution-phase peptide assembly.

General Information

CAS No. 1247791-23-6
Cat. No. CS-0375938
Purity ≥98%
MDL No. MFCD06796896
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₂₁NO₆S
Molecular Weight 403.45
Synonym(s) Fmoc-D-methionine sulfone
SMILES O=C(O)[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CCS(=O)(C)=O

Computational Chemistry Data

TPSA 109.77
LogP 2.413
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 7

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Methionine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid

CAS No. 1247791-23-6

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