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Structure of 125096-73-3
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4-Chloro-8-iodoquinazoline is a bifunctional heterocyclic scaffold enabling efficient cross-coupling and bioconjugation strategies. The chlorine and iodine substituents at the 4- and 8-positions, respectively, provide orthogonal reactivity for palladium-catalyzed transformations. This electron-deficient quinazoline core supports modular synthesis of kinase inhibitors and targeted therapeutics.
4-Chloro-8-iodoquinazoline serves as a versatile bifunctional building block for transition-metal-catalyzed cross-coupling reactions. The chloro group enables palladium-mediated coupling with arylboranes and amines, while the iodo substituent offers high reactivity in Suzuki-Miyaura and Buchwald-Hartwig transformations. Its bench-stable nature and orthogonal reactivity profile facilitate sequential functionalization in the synthesis of quinazoline-based pharmaceutical scaffolds and kinase inhibitors.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: