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tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate

  • CAS No. 1250994-14-9

  • Cat. No. CS-0037089
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate|CS-0037089

Structure of 1250994-14-9

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General Information

  • CAS No. 1250994-14-9
  • Cat. No. CS-0037089
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃NO₃
  • Molecular Weight 253.34
  • Synonym(s) tert-butyl 3-oxo-8-azaspiro[4.5]decane-8-carboxylate
  • SMILES CC(C)(C)OC(=O)N1CCC2(CCC(=O)C2)CC1

Description

tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate is a sterically shielded spirocyclic carbamate featuring a ketone and a latent amine within a rigid 8-azaspiro[4.5]decane framework. This bench-stable, moisture-tolerant building block enables efficient access to complex nitrogen-containing scaffolds in medicinal chemistry and natural product synthesis.

Application

tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate serves as a versatile spirocyclic building block for medicinal chemistry and natural product synthesis. The constrained spirocyclic framework imparts rigidity, while the ketone and ester functionalities enable selective functionalization via enolate chemistry, reductive amination, or nucleophilic addition. Bench-stable and amenable to standard purification methods, it facilitates efficient access to complex nitrogen-containing scaffolds relevant to drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   2.7567
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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