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tert-Butyl 3-(piperidin-3-yl)azetidine-1-carboxylate

  • CAS No. 1251006-73-1

  • Cat. No. CS-0079213
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD14581438

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-(piperidin-3-yl)azetidine-1-carboxylate|CS-0079213

Structure of 1251006-73-1

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General Information

  • CAS No. 1251006-73-1
  • Cat. No. CS-0079213
  • Purity ≥95%
  • MDL No. MFCD14581438
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₄N₂O₂
  • Molecular Weight None
  • Synonym(s) tert-butyl 3-(piperidin-3-yl)-azetidine-1-carboxylate
  • SMILES O=C(N1CC(C2CNCCC2)C1)OC(C)(C)C

Description

tert-Butyl 3-(piperidin-3-yl)azetidine-1-carboxylate features a strained azetidine ring fused to a piperidine moiety, delivering enhanced metabolic stability and improved membrane permeability. This scaffold integrates readily into medicinal chemistry campaigns targeting CNS disorders and kinase inhibitors, offering high functional group tolerance and compatibility with standard coupling protocols.

Application

tert-Butyl 3-(piperidin-3-yl)azetidine-1-carboxylate serves as a versatile scaffold for medicinal chemistry campaigns, enabling rapid access to constrained azetidine-containing analogs. The tert-butyl carbamate group provides excellent bench stability and orthogonal deprotection compatibility, while the piperidin-3-yl moiety offers favorable conformational preorganization and hydrogen-bonding capacity. This compound facilitates efficient late-stage diversification via standard coupling reactions and functions as a key building block in the synthesis of bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.8529
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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