tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate

Name: tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate
Brand: ChemScene
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CAS No. 219725-67-4
Cat. No. CS-0012548
Molecule weight241.34
Purity≥95%
MDL No.MFCD09264437

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tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate|CS-0012548

Structure of 219725-67-4

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General Information

CAS No. 219725-67-4
Cat. No. CS-0012548
Purity ≥95%
MDL No. MFCD09264437
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₃N₃O₂
Molecular Weight 241.34
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CCN(CC1)C2CNC2

Description

tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate features a rigid azetidine ring fused to a piperazine scaffold, delivering enhanced metabolic stability and improved membrane permeability. This protected amine integrates efficiently into complex molecular architectures, serving as a key intermediate in the synthesis of bioactive compounds with defined spatial orientation.

Application

tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds. The azetidine moiety provides enhanced metabolic stability and improved pharmacokinetic properties, while the piperazine core offers multiple sites for functionalization. This compound exhibits excellent bench stability, facilitates efficient coupling reactions, and supports orthogonal protection strategies in multi-step syntheses.

Safety Information

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GHS Pictogram :	GHS No : GHS09
Signal Word : N/A	UN#: 3077
Class : 9	Packing Group : Ⅲ
Hazard Statements : H411
Precautionary Statements : P273-P391-P501

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Computational Chemistry Data

TPSA 44.81
LogP 0.5109
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Life Science Linker Non-PEG linker

Key Words

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tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate

CAS No. 219725-67-4

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