5-(tert-Butoxycarbonyl)-5-azaspiro[2.3]hexane-1-carboxylic acid

Name: 5-(tert-Butoxycarbonyl)-5-azaspiro[2.3]hexane-1-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 1251012-82-4
Cat. No. CS-0038518
Purity≥97%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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5-(tert-Butoxycarbonyl)-5-azaspiro[2.3]hexane-1-carboxylic acid|CS-0038518

Structure of 1251012-82-4

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Description

This spirocyclic carboxylic acid features a tert-butyl carbamate-protected amine and a sterically hindered bicyclic core, enabling stable incorporation into complex scaffolds. The Boc group allows for selective deprotection under mild acidic conditions, facilitating downstream functionalization in medicinal chemistry applications.

Application

5-(tert-Butoxycarbonyl)-5-azaspiro[2.3]hexane-1-carboxylic acid serves as a versatile spirocyclic building block for medicinal chemistry campaigns, enabling efficient access to constrained heterocyclic scaffolds. The Boc-protected amine and carboxylic acid functionality offer orthogonal reactivity for sequential derivatization, while the spirocyclic core provides conformational rigidity beneficial in target-oriented synthesis. Bench-stable and readily purified by standard chromatography, it functions reliably in peptide coupling, macrocyclization, and transition metal-catalyzed transformations.

General Information

CAS No. 1251012-82-4
Cat. No. CS-0038518
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₇NO₄
Molecular Weight 227.26
Synonym(s) 5-dicarboxylic acid 5-tert-butyl ester
SMILES CC(C)(C)OC(=O)N1CC2(CC2C(=O)O)C1

Computational Chemistry Data

TPSA 66.84
LogP 1.328
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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5-(tert-Butoxycarbonyl)-5-azaspiro[2.3]hexane-1-carboxylic acid

CAS No. 1251012-82-4

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