6-Fluoroquinolin-5-amine

Name: 6-Fluoroquinolin-5-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1251032-63-9
Cat. No. CS-0128177
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 1251032-63-9

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Description

6-Fluoroquinolin-5-amine features a fluorine atom at the 6-position and a primary amine at the 5-position of the quinoline scaffold, delivering enhanced electron-withdrawing character and improved solubility in polar solvents. This combination enables efficient coupling reactions in medicinal chemistry applications, particularly in the synthesis of kinase inhibitors and fluorescent probes.

Application

6-Fluoroquinolin-5-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation into kinase inhibitors and other bioactive heterocycles. Its fluorinated quinoline core offers enhanced metabolic stability and improved membrane permeability. The amine functionality facilitates coupling reactions (e.g., Suzuki, Buchwald–Hartwig), while the fluorine substituent provides orthogonal reactivity for downstream modifications. Bench-stable and readily purified by chromatography or recrystallization, it functions reliably in multi-step syntheses of pharmaceutical candidates.

General Information

CAS No. 1251032-63-9
Cat. No. CS-0128177
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₇FN₂
Molecular Weight 162.16
Synonym(s) None
SMILES NC1=C2C=CC=NC2=CC=C1F

Computational Chemistry Data

TPSA 38.91
LogP 1.9561
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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6-Fluoroquinolin-5-amine

CAS No. 1251032-63-9

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