6-Bromo-3-chloro-2-methoxypyridine

Name: 6-Bromo-3-chloro-2-methoxypyridine
Brand: ChemScene
Availability: InStock
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CAS No. 1256810-58-8
Cat. No. CS-0150234
Purity≥95%
MDL No.MFCD18257583

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-3-chloro-2-methoxypyridine|CS-0150234

Structure of 1256810-58-8

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Description

6-Bromo-3-chloro-2-methoxypyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling and functionalization. The bromo group at C6 enables palladium-catalyzed transformations, while the chloro substituent at C3 offers orthogonal reactivity. The methoxy group at C2 enhances solubility and modulates electronic properties, facilitating efficient incorporation into complex heterocyclic architectures under standard conditions.

Application

6-Bromo-3-chloro-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates efficient C–C bond formation, while the chloro and methoxy functionalities offer orthogonal functionalization potential. Its bench-stable nature and clean purification profile support scalable synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

General Information

CAS No. 1256810-58-8
Cat. No. CS-0150234
Purity ≥95%
MDL No. MFCD18257583
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrClNO
Molecular Weight 222.47
Synonym(s) CJXSBRMPNXLISI-UHFFFAOYSA-N
SMILES COC1=NC(=CC=C1Cl)Br

Computational Chemistry Data

TPSA 22.12
LogP 2.5061
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Bromo-3-chloro-2-methoxypyridine

CAS No. 1256810-58-8

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