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CS-W001157 4
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5-Bromo-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 1256818-80-0

  • Cat. No. CS-0163684
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridine|CS-0163684

Structure of 1256818-80-0

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General Information

  • CAS No. 1256818-80-0
  • Cat. No. CS-0163684
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉BrN₂
  • Molecular Weight 237.10
  • Synonym(s) None
  • SMILES BrC1=CN=C(NC=C2C3CC3)C2=C1

Description

5-Bromo-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridine is a sterically defined heterocyclic scaffold featuring a brominated pyrrolopyridine core with a cyclopropyl substituent at the 3-position. This configuration enhances metabolic stability and facilitates transition-metal-catalyzed coupling reactions. The molecule exhibits favorable solubility in common organic solvents and maintains bench stability under standard conditions.

Application

5-Bromo-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds. The bromine substituent enables palladium-catalyzed cross-coupling reactions, while the cyclopropyl group enhances metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in standard synthetic workflows for medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   3.2028
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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