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CS-W001157 4
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2-Bromo-5-chloro-3-(trifluoromethyl)pyridine

  • CAS No. 1256820-00-4

  • Cat. No. CS-0041349
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-chloro-3-(trifluoromethyl)pyridine|CS-0041349

Structure of 1256820-00-4

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General Information

  • CAS No. 1256820-00-4
  • Cat. No. CS-0041349
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂BrClF₃N
  • Molecular Weight 260.44
  • Synonym(s) None
  • SMILES FC(C1=CC(Cl)=CN=C1Br)(F)F

Description

2-Bromo-5-chloro-3-(trifluoromethyl)pyridine is a halogenated pyridine derivative featuring orthogonal reactivity at bromo and chloro sites. The trifluoromethyl group imparts enhanced electron-withdrawing character and metabolic stability, enabling efficient cross-coupling transformations. This compound serves as a key building block in pharmaceutical synthesis, particularly for heterocyclic scaffolds requiring precise substitution patterns.

Application

2-Bromo-5-chloro-3-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the bromo and chloro substituents allow sequential functionalization. Bench-stable and compatible with standard synthetic workflows, it facilitates the construction of complex heterocyclic scaffolds found in pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.5163
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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