6-Bromo-5-fluoropyridin-2-amine

Name: 6-Bromo-5-fluoropyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1257294-51-1
Cat. No. CS-0029938
Purity≥97%
MDL No.MFCD26407134

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-5-fluoropyridin-2-amine|CS-0029938

Structure of 1257294-51-1

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Description

6-Bromo-5-fluoropyridin-2-amine features a pyridine core bearing bromo and fluoro substituents at the 6- and 5-positions, respectively, with an amino group at C2. This electron-deficient heterocycle serves as a key scaffold for coupling reactions in medicinal chemistry, enabling efficient diversification in target-oriented synthesis. The molecule exhibits enhanced reactivity in palladium-catalyzed cross-coupling processes due to the synergistic influence of the halogen atoms.

Application

6-Bromo-5-fluoropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromine and fluorine substituents offer orthogonal functionalization potential, while the primary amine facilitates conjugation or derivatization. Its stability under standard bench conditions and compatibility with diverse reaction protocols make it a practical choice for constructing complex heterocyclic scaffolds and API intermediates.

General Information

CAS No. 1257294-51-1
Cat. No. CS-0029938
Purity ≥97%
MDL No. MFCD26407134
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrFN₂
Molecular Weight 191.00
Synonym(s) 6-bromo-5-fluoro-pyridin-2-ylamine
SMILES NC1=NC(Br)=C(F)C=C1

Computational Chemistry Data

TPSA 38.91
LogP 1.5654
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Bromo-5-fluoropyridin-2-amine

CAS No. 1257294-51-1

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