6-Chloro-3-fluoropyridin-2-amine

Name: 6-Chloro-3-fluoropyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1260672-14-7
Cat. No. CS-0196637
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-3-fluoropyridin-2-amine|CS-0196637

Structure of 1260672-14-7

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Description

6-Chloro-3-fluoropyridin-2-amine features a trifunctional heterocyclic core with strategically positioned halogen substituents. The ortho-chloro and meta-fluoro groups enable selective cross-coupling reactions, while the pyridin-2-amine handle facilitates metal coordination and derivatization. This scaffold delivers enhanced reactivity in transition-metal-catalyzed transformations under standard conditions.

Application

6-Chloro-3-fluoropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its orthogonal halogen functionality facilitates palladium-catalyzed cross-coupling reactions, while the primary amine supports derivatization via acylation, alkylation, or reductive amination. The compound exhibits excellent bench stability and compatibility with standard synthetic workflows, making it well-suited for the construction of kinase inhibitors and other bioactive molecules.

General Information

CAS No. 1260672-14-7
Cat. No. CS-0196637
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClFN₂
Molecular Weight 146.55
Synonym(s) 2-Amino-6-chloro-3-fluoropyridine
SMILES C1=CC(=NC(=C1F)N)Cl

Computational Chemistry Data

TPSA 38.91
LogP 1.4563
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-3-fluoropyridin-2-amine

CAS No. 1260672-14-7

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