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CS-W001157 4
Total: USD 88.00

5-Bromo-1,2,3,4-tetrahydroisoquinolin-8-amine

  • CAS No. 1260779-54-1

  • Cat. No. CS-0041900
  • Purity≥98%
  • MDL No.MFCD13193651

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1,2,3,4-tetrahydroisoquinolin-8-amine|CS-0041900

Structure of 1260779-54-1

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General Information

  • CAS No. 1260779-54-1
  • Cat. No. CS-0041900
  • Purity ≥98%
  • MDL No. MFCD13193651
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BrN₂
  • Molecular Weight 227.10
  • Synonym(s) None
  • SMILES NC1=CC=C(Br)C2=C1CNCC2

Description

5-Bromo-1,2,3,4-tetrahydroisoquinolin-8-amine features a brominated tetrahydroisoquinoline core with a primary amine at the 8-position, enabling direct functionalization in synthetic routes. The electron-deficient aromatic system enhances reactivity in coupling reactions, while the saturated ring ensures conformational stability and improved solubility in polar solvents. This scaffold serves as a key intermediate for bioactive molecule synthesis.

Application

5-Bromo-1,2,3,4-tetrahydroisoquinolin-8-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through palladium-catalyzed cross-coupling reactions. The bromo group facilitates efficient functionalization, while the primary amine offers direct derivatization pathways. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses targeting CNS-active compounds and kinase inhibitors.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.677
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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