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Structure of 1260782-19-1
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2-Chloro-5-(trifluoromethyl)isonicotinonitrile features a trifluoromethyl group and nitrile functionality at the 5- and 2-positions of the isonicotinonitrile core, delivering strong electron-withdrawing character. This configuration enhances reactivity in cross-coupling and heterocyclic synthesis. The molecule exhibits bench-stability and compatibility with diverse reaction conditions, enabling efficient incorporation into complex molecular architectures.
2-Chloro-5-(trifluoromethyl)isonicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its trifluoromethyl and nitrile groups confer enhanced metabolic stability and favorable lipophilicity, while the chlorine facilitates selective functionalization. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for scalable synthesis of pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: