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CS-W001157 4
Total: USD 88.00

(4-Amino-2,6-difluorophenyl)methanol

  • CAS No. 1260838-76-3

  • Cat. No. CS-0540259
  • Molecule weight159.13
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Amino-2,6-difluorophenyl)methanol|CS-0540259

Structure of 1260838-76-3

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General Information

  • CAS No. 1260838-76-3
  • Cat. No. CS-0540259
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₂NO
  • Molecular Weight 159.13
  • Synonym(s) None
  • SMILES OCC1=C(F)C=C(N)C=C1F

Description

(4-Amino-2,6-difluorophenyl)methanol features a benzene ring bearing electron-rich amino and sterically accessible difluoro substituents, enabling direct incorporation into bioactive scaffolds. The primary alcohol facilitates derivatization under standard conditions, while the para-amino group enhances solubility and reactivity in synthetic sequences.

Application

(4-Amino-2,6-difluorophenyl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic scaffolds. Its primary alcohol functionality facilitates straightforward derivatization via esterification, etherification, or coupling reactions, while the ortho-fluoro substituents enhance metabolic stability and modulate electronic properties. The amine group provides additional handles for conjugation or further functionalization, offering synthetic flexibility in the construction of bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.0393
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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