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Structure of 1261169-72-5
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(2,3-Difluoro-4-hydroxyphenyl)boronic acid features a hydroxyl group flanked by two fluorine atoms on the aromatic ring, enhancing its electron-deficient character and stability. This configuration enables efficient Suzuki-Miyaura coupling under standard conditions, delivering arylated products with high fidelity. The boronic acid moiety is bench-stable and moisture-tolerant, simplifying handling in synthetic workflows.
(2,3-Difluoro-4-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of fluorinated biaryls and heterocyclic scaffolds. The ortho-difluoro substitution enhances metabolic stability and modulates electronic properties, while the boronic acid group offers excellent bench stability and compatibility with aqueous workups. Its utility in medicinal chemistry is supported by predictable reactivity and straightforward purification, making it a reliable reagent for target-oriented synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: