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CS-W001157 4
Total: USD 88.00

(2,6-Difluoro-4-hydroxyphenyl)boronic acid

  • CAS No. 957065-87-1

  • Cat. No. CS-0100645
  • Purity≥96%
  • MDL No.MFCD09878344
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(2,6-Difluoro-4-hydroxyphenyl)boronic acid|CS-0100645

Structure of 957065-87-1

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Description

This boronic acid features a difluorinated aromatic ring paired with a hydroxyl group, enabling enhanced solubility and stability in aqueous environments. The para-hydroxy functionality facilitates direct coupling in Suzuki-Miyaura reactions, while the ortho-fluorine substituents improve reactivity through electronic activation. Designed for bench-stable handling, it integrates efficiently into complex synthesis workflows requiring precise functional group compatibility.

Application

(2,6-Difluoro-4-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of substituted biaryls and heteroaryl architectures. The ortho-difluoro substitution enhances electrophilic reactivity and improves metabolic stability in downstream pharmaceutical candidates. Its boronic acid functionality offers excellent bench stability, compatibility with diverse reaction conditions, and straightforward purification via standard aqueous workup.

General Information

  • CAS No. 957065-87-1
  • Cat. No. CS-0100645
  • Purity ≥96%
  • MDL No. MFCD09878344
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BF₂O₃
  • Molecular Weight 173.91
  • Synonym(s) 4-Borono-3,5-difluorophenol
  • SMILES OB(C1=C(F)C=C(O)C=C1F)O

Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.6498
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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