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Structure of 1261216-28-7
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5-Bromo-2-chloro-1-fluoro-3-methoxybenzene features a strategically substituted aromatic core enabling precise functionalization in cross-coupling and electrophilic substitution reactions. The trifunctional aryl halide system—bearing bromine, chlorine, and fluorine—permits sequential transformations under orthogonal conditions. This electron-deficient platform integrates readily into complex molecular architectures with high chemoselectivity and stability under standard bench protocols.
5-Bromo-2-chloro-1-fluoro-3-methoxybenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity profile. The ortho-chloro and meta-bromo substituents facilitate selective functionalization, while the methoxy group provides electronic modulation and enhanced solubility. Bench-stable and amenable to standard purification methods, it functions reliably in Suzuki, Stille, and Negishi coupling workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: