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Structure of 146447-18-9
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1-Bromo-4-chloro-2-fluoro-5-methoxybenzene offers a strategically positioned trifluorinated aryl scaffold with orthogonal reactivity. The bromine site enables palladium-catalyzed cross-coupling, while the methoxy group enhances solubility and modulates electronic effects. This electron-deficient platform is bench-stable and compatible with standard synthetic protocols in medicinal chemistry and materials synthesis.
1-Bromo-4-chloro-2-fluoro-5-methoxybenzene serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig arylations. The molecule’s orthogonal halogen reactivity—bromine for coupling, chlorine and fluorine for stability—facilitates sequential functionalization. Its methoxy group provides a handle for further derivatization or modulation of electronic properties. Bench-stable and compatible with standard purification methods, it supports scalable synthesis of complex aromatic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: