4-Chloro-3-methoxypyridin-2-amine

Name: 4-Chloro-3-methoxypyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1261452-97-4
Cat. No. CS-0162479
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-3-methoxypyridin-2-amine|CS-0162479

Structure of 1261452-97-4

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Description

4-Chloro-3-methoxypyridin-2-amine features a pyridine core bearing chloro and methoxy substituents at adjacent positions, enabling precise tuning of electronic and steric properties. This bench-stable heterocycle integrates readily into synthetic routes for pharmaceutical intermediates, leveraging its reactive amine handle and electron-deficient ring system to support efficient coupling reactions under standard conditions.

Application

4-Chloro-3-methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chlorine and amine functionalities offer orthogonal reactivity for sequential derivatization, while the methoxy group enhances solubility and modulates electronic properties. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development and heterocycle functionalization.

General Information

CAS No. 1261452-97-4
Cat. No. CS-0162479
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) None
SMILES NC1=NC=CC(Cl)=C1OC

Computational Chemistry Data

TPSA 48.14
LogP 1.3258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-3-methoxypyridin-2-amine

CAS No. 1261452-97-4

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