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Structure of 1261728-71-5
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7-(Difluoromethyl)quinoline is a fluorinated heterocyclic scaffold featuring a difluoromethyl group at the 7-position of quinoline. This substitution imparts enhanced electron-withdrawing character and metabolic stability, enabling its use in medicinal chemistry for targeted kinase inhibition and as a bioisostere in drug design.
7-(Difluoromethyl)quinoline serves as a valuable building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive scaffolds. Its quinoline core provides a rigid, planar framework with favorable pharmacokinetic properties, while the difluoromethyl substituent offers enhanced metabolic stability and modulated lipophilicity. The functional group exhibits good bench stability and compatibility with standard coupling reactions, facilitating efficient derivatization in late-stage functionalization strategies.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: